論文雑誌「JACS」のカバーピクチャーを制作しました［微生物化学研究所］
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アメリカ化学会発行の学術雑誌 JACS 2022年9月号に選ばれました。
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公益財団法人 微生物化学研究会
微生物化学研究所 有機合成研究部
渡辺匠様
微生物化学研究所 有機合成研究部
渡辺匠様
Journal
Journal of the American Chemical Society
September 28, 2022, Volume 144, Issue 38 Link
September 28, 2022, Volume 144, Issue 38 Link
Targeting the ATG5-ATG16L1 Protein–Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition
Jin Cui, Yuta Ogasawara, Ikuko Kurata, Kazuaki Matoba, Yuko Fujioka, Nobuo N. Noda*, Masakatsu Shibasaki, and Takumi Watanabe*
The ATG12–ATG5–ATG16L1 complex formation is essential for targeting the ATG12–ATG5 conjugate to proper membranes and to generate LC3-II for the progression of autophagy. A stapled peptide derived from ATG16L1 exhibits potent binding affinity to ATG5, striking resistance to proteolysis, and significant autophagy inhibition activities in cells.
Link
Jin Cui, Yuta Ogasawara, Ikuko Kurata, Kazuaki Matoba, Yuko Fujioka, Nobuo N. Noda*, Masakatsu Shibasaki, and Takumi Watanabe*
The ATG12–ATG5–ATG16L1 complex formation is essential for targeting the ATG12–ATG5 conjugate to proper membranes and to generate LC3-II for the progression of autophagy. A stapled peptide derived from ATG16L1 exhibits potent binding affinity to ATG5, striking resistance to proteolysis, and significant autophagy inhibition activities in cells.
Link
